2-(2-Chlorophenyl)-N-cyclohexyl-2-oxoacetamide
نویسندگان
چکیده
منابع مشابه
2-(2-Chlorophenyl)-N-cyclohexyl-2-oxoacetamide
In the title compound, C14H16ClNO2, the cyclo-hexyl ring has a chair conformation. The dihedral angle between the benzene ring and the mean plane of the four planar C atoms of the cyclo-hexyl ring is 45.2 (3)°. The two carbonyl groups are trans to one another, with an O=C-C=O torsion angle of -137.1 (3)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds forming chains propagating a...
متن کاملThe effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide.
In the title compounds, C(10)H(8)N(2)O(2), (I), and C(12)H(12)N(2)O(2), (II), the two carbonyl groups are oriented with torsion angles of -149.3 (3) and -88.55 (15)°, respectively. The single-bond distances linking the two carbonyl groups are 1.528 (4) and 1.5298 (17) Å, respectively. In (I), the molecules are linked by an elaborate system of N-H···O hydrogen bonds, which form adjacent R(2)(2)(...
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In this study, a series of novel N-substituted 2-(2-(adamantan-1-yl)-1H-indol-3-yl)-2-oxoacetamide derivatives were synthesized, and evaluated for their cytotoxicity in human cell lines including Hela (cervical cancer), MCF7 (breast cancer ) and HepG2 (liver cancer). Several compounds were found to have potent anti-proliferative activity against those human cancer cell lines and compound 5r sho...
متن کاملN-Cyclohexyl-2-(5-methoxy-1H-indol-3-yl)-2-oxoacetamide
In the title compound, C(17)H(20)N(2)O(3), the cyclo-hexane ring adopts a chair conformation. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into layers parallel to the ac plane.
متن کامل2-(1-Ethyl-5-methoxy-1H-indol-3-yl)-N-isopropyl-2-oxoacetamide
In the title compound, C(16)H(20)N(2)O(3), the crystal packing is stabilized by weak π-π stacking inter-actions [centroid-centroid distances = 3.577 (9) and 3.693 (9) Å] and inter-molecular C-H⋯O and N-H⋯O hydrogen-bond inter-actions. The C atoms of the N-isopropyl group are disordered over two sets of sites with occupancies of 0.61(3) and 0.39(3).
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2013
ISSN: 1600-5368
DOI: 10.1107/s1600536813005904